|Arm-cycling for poststroke walking rehabilitation|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Dr. E. Paul Zehr (University of Victoria, British Columbia) about new study which explores whether training the arms may influence the rehabilitation of walking following stroke. Learn about locomotor central pattern-generating networks, cutaneous reflex modulation, interlimb connectivity, and more!
Associated article:Rhythmic arm cycling training improves walking and neurophysiological integrity in chronic stroke: the arms can give legs a helping hand in rehabilitation
by Chelsea Kaupp, Gregory E. P. Pearcey, Taryn Klarner, Yao Sun, Hilary Cullen, Trevor S. Barss, and E. Paul Zehr; published online March 8, 2018 DOI: 10.1152/jn.00570.2017
|Tactile perception of the roughness of 3D-printed textures|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Chelsea Tymms (NYU) and Dr. Esther Gardner (NYU) about their new study, which was chosen for January's issue of APSselect. This study investigated in human subjects how estimations of roughness vary for precisely defined, 3D-printed surfaces.
Associated article:Tactile perception of the roughness of 3D-printed textures
by Chelsea Tymms, Denis Zorin, and Esther P. Gardner; published online March 1, 2018 DOI: 10.1152/jn.00564.2017
|Neural computations for action recognition|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Dr. Leyla Isik (MIT) about a new study which uses neural imaging and computational modeling to investigate the ways that defined actions are encoded across changes in viewpoint. Learn about complex visual transformations, computer vision algorithms, the importance of neural timing, and more!
Associated article:A fast, invariant representation for human action in the visual system
by Leyla Isik, Andrea Tacchetti, and Tomaso Poggio; published online February 13, 2018 DOI: 10.1152/jn.00642.2017
|Response inhibition in M1|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Matthew Cowie, Dr. John Cirillo, and Dr. Winston Byblow (all from the University of Auckland) about a new study which uses informative and uninformative cues along with TMS to investigate long- and short-interval intracortical inhibition during response inhibtion tasks. Learn about the paradigms used, the role of GABA, and more!
Associated article:Response inhibition activates distinct motor cortical inhibitory processes
by John Cirillo, Matthew J. Cowie, Hayley J. MacDonald, Winston D. Byblow; published online December 6, 2017 DOI: 10.1152/jn.00784.2017
|Updating the role of force feedback in the spinal cord|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Richard Nichols (Georgia Tech) about a new review article which explores recent research on distributed force feedback and motor control. Listen to learn about historical views, new results, and future work on the role played by Golgi tendon organs in regulating mechanics during voluntary limb movement.
Associated article:Distributed force feedback in the spinal cord and the regulation of limb mechanics
by T. Richard Nichols; published online December 6, 2017 DOI: 10.1152/jn.00216.2017
|A new paradigm for training rhesus monkeys|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Dr. Michael Berger (German Primate Center), Dr. Antonino Calapai (German Primate Center), and Dr. Valeska Stephan (German Primate Center) about their new across-task unsupervised training (AUT) paradigm for rhesus monkeys in neuroscience research settings. The discussion focuses on a recent study on the effectiveness, benefits, and challenges of using the AUT.
Associated article:Standardized automated training of rhesus monkeys for neuroscience research in their housing environment
by Michael Berger, Antonino Calapai, Valeska Stephan, Michael Niessing, Leonore Burchardt, Alexander Gail, and Stefan Treue; published online November 15, 2017 DOI: 10.1152/jn.00614.2017
|Breathing above the brain stem|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Dr. Jose Herrero (Northwell Health; Feinstein Institute for Medical Research) and Dr. Ashesh Mehta (Northwell Health; Feinstein Institute for Medical Research) about their study which provides a novel look at the tracking of the breathing cycle in widespread cortical and limbic sites in humans. Learn about the recording methods employed, the types of activity discovered, and the implications for volitional control and awareness of breathing!
Associated article:Breathing above the brain stem: volitional control and attentional modulation in humans
by Jose L. Herrero, Simon Khuvis, Erin Yeagle, Moran Cerf, and Ashesh D. Mehta; published online January 3, 2018 DOI: 10.1152/jn.00551.2017
|ADHD and tactile processing|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Dr. Nicolaas Puts (Johns Hopkins University School of Medicine; Kennedy Krieger Institute) and Dr. Stewart Mostofsky (Johns Hopkins University School of Medicine; Kennedy Krieger Institute) about a new study which employed recent innovations in neuroimaging to examine whether children with ADHD showed impaired performance on tactile tasks related to GABAergic inhibitory control.
Associated article:Altered tactile sensitivity in children with attention-deficit hyperactivity disorder
by Nicolaas A. J. Puts, Ashley D. Harris, Mark Mikkelsen, Mark Tommerdahl, Richard A. E. Edden, and Stewart H. Mostofsky; published online November 30, 2017 DOI: 10.1152/jn.00087.2017
|Tests of the sorption and olfactory ‘fovea’ hypotheses in the mouse|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Professor David Coppola (Randolph-Macon College, Ashland, Virginia) about a recent article which provides a novel test of the longstanding “sorption hypothesis” and related "fovea hypothesis", which posit that physical properties of odors, such as volatility and water solubility, determine a spatial pattern of stimulation across the OE that could aid odor discrimination.
Associated article:Tests of the sorption and olfactory "fovea" hypotheses in the mouse
by David M. Coppola, Brittaney E. Ritchie, and Brent A. Craven; published online November 7, 2017 DOI: 10.1152/jn.00455.2017
|Acetylcholine and the efferent vestibular system|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Lauren Poppi (University of Newcastle, Australia) and Alan Brichta (University of Newcastle, Australia) about their recent article in which they expore the hypothesis that "the reduction in afferent sensitivity was attributed, in part, to the activation of alpha9-containing nAChRs ( 9nAChRs) and small-conductance potassium channels (SK) in vestibular type II hair cells.
Associated article:ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells
by Lauren Ashlee Poppi, Hessam Tabatabaee, Hannah Rose Drury, Phillip Jobling, Robert J. Callister, Americo A. Migliaccio, Paivi M. Jordan, Joseph Christopher Holt, Richard D. Rabbitt, Rebecca Lim, and Alan Martin Brichta; published online November 14, 2017 DOI: 10.1152/jn.00030.2017
|A case study on camptocormia|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Rebecca St. George (University of Tasmania) and Fay Horak (Oregon Health and Science University) about the very first "Case Study in Neuroscience" article published in the Journal of Neurophysiology. The authors completed a wide variety of tests and found that "the disorder in this case was due to a disruption in the automatic, tonic drive to the postural muscles and myogenic changes were secondary," which demonstrates a divergence in the neural control of balance and posture.
Associated article:Case Studies in Neuroscience: A Dissociation of Balance and Posture Demonstrated by Camptocormia
by Rebecca J. St George, Victor S. Gurfinkel, Jeff Kraakevik, John G. Nutt, Fay B. Horak; published online October 4, 2017 DOI: 10.1152/jn.00582.2017
|Neural oscillations and phase-amplitude coupling in Parkinson’s disease|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with David Escobar Sanabria (Department of Neurology, University of Minnesota) and Luke Johnson (Department of Neurology, University of Minnesota) about a recent study which sought to characterize biomarkers for Parkinson's disease across various vigilance states, and to build a foundation for future closed-loop DBS therapeutic techniques.
Associated article:Parkinsonism and vigilance: alteration in neural oscillatory activity and phase-amplitude coupling in the basal ganglia and motor cortex
by David Escobar Sanabria, Luke A. Johnson, Shane D. Nebeck, Jianyu Zhang, Matthew D. Johnson, Kenneth B. Baker, Gregory F. Molnar, Jerrold L. Vitek; published online November 3, 2017 DOI: 10.1152/jn.00388.2017
|A frequency-dependent dual role for Aβ afferents during dynamic mechanical allodynia|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Line Loken (UCSF) about a recent study which surprisingly found an inverse relationship between Aβ firing rates and unpleasantness following capsaicin-induced dynamic mechanical allodynia.
Associated article:Low-threshold mechanoreceptors play a frequency-dependent, dual role in subjective ratings of mechanical allodynia
by Line Sofie Loken, Eugene Duff, Irene Tracey; published online September 27, 2017 DOI: 10.1152/jn.00977.2016
|Standardizing the divisive-normalization model of V1 neurons|
Watch as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Tadamasa Sawada (National Research University Higher School of Economics, Moscow) about a recent study which sought to standardize the DNM, the testing and verification of this new model, and some predictions that resulted from analyzing the model.
Associated article:The Divisive-Normalization Model of V1 Neurons: A Comprehensive Comparison of Physiological Data and Model Predictions
by Tadamasa Sawada, Alexander A. Petrov; published online August 23, 2017 DOI: 10.1152/jn.00821.2016
|Early psychosocial neglect and developing brain networks|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Caterina Stamoulis (Harvard Medical School and Boston Children's Hospital) about findings from the Bucharest Early Intervention Project (BEIP) which demonstrated aberrantly connected task-independent brain networks in children that had been raised in institutions.
Associated article:Neuronal networks in the developing brain are adversely modulated by early psychosocial neglect
by Catherine Stamoulis, Ross E. Vanderwert, Charles H. Zeanah, Nathan A. Fox, Charles A. Nelson; published online October 5, 2017 DOI: 10.1152/jn.00014.2017
|Multiple sclerosis and reduced somatosensory gating|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Dave Arpin (University of Louisville) about a new study which sought to examine the neural basis of somatosensory gating and to assess the relationship between somatosensory gating and walking performance in patients with MS and healthy controls.
Associated article:A reduced somatosensory gating response in individuals with multiple sclerosis is related to walking impairment
by David J. Arpin, James E. Gehringer, Tony W. Wilson, Max J. Kurz; published online July 19, 2017 DOI: 10.1152/jn.00260.2017
|Caffeine accelerates emergence from anesthesia|
Listen as Editor-in-Chief Bill Yates (University of Pittsburgh) talks with Jimmy Xie, Robert Fong, and Aaron Fox (all from the University of Chicago) about a new study that shows that caffeine is effective even at high levels of anesthetic, and which explores the mechanisms underlying this finding.
Associated article:Caffeine accelerates recovery from general anesthesia via multiple pathways
by Robert Fong, Suhail Khokhar, Atif N. Chowdhury, Kelvin G. Xie, Josiah Hiu-Yuen Wong, Aaron P. Fox, Zheng Xie; published online September 1, 2017 DOI: 10.1152/jn.00393.2017
|A state-space approach to quantifying common motor input|
Listen as Dan Feeney (University of Colorado, Boulder) discusses the history of quantifying common motor input, a new state-space model approach to the problem, and the experimental findings which validated this model.
Associated article:A latent low-dimensional common input drives a pool of motor neurons: a probabilistic latent state-space model
by Daniel F. Feeney, Francois G. Meyer, Nicholas Noone, Roger M. Enoka; published online August 2, 2017 DOI: 10.1152/jn.00274.2017
|Reduced neural responses to the taste of alcohol following fetal alcohol exposure|
Listen as Steven Youngentob (UTHSC) and John Glendinning (Barnard College, Columbia) discuss the history, recent progress, and future of their work exploring taste response to alcohol in rats.
Associated article:Fetal alcohol exposure reduces responsiveness of taste nerves and trigeminal chemosensory neurons to ethanol and its flavor components
by John I. Glendinning, Joyce Tang, Ana Paula Morales Allende, Bruce P. Bryant, Lisa Youngentob, Steven L. Youngentob; published online May 10, 2017 DOI: 10.1152/jn.00108.2017
|Increased neuromuscular consistency in gait and balance after partnered, dance-based rehabilitation in Parkinson’s disease|
Listen as the authors of a recently published study discuss their work using motor module analysis to investigate the improvements in gait, balance, and coordination shown by Parkinson’s patients after three weeks of learning adapted Tango.
Associated article:Increased neuromuscular consistency in gait and balance after partnered, dance-based rehabilitation in Parkinson’s disease
by Jessica L. Allen, J. Lucas McKay, Andrew Sawers, Madeleine Eve Hackney, Lena H. Ting; published online April 5, 2017 DOI: 10.1152/jn.00813.2016
|Multiple sclerosis and thermoregulatory control|
Listen as Scott Davis (SMU) and Dustin Allen (SMU) discuss their work examining the reflex control of thermoregulatory responses to a passive heat stress in individuals with MS.
Associated article:Impaired sweating responses to a passive whole-body heat stress in individuals with multiple sclerosis
by Dustin R. Allen, Mu Huang, Iqra M. Parupia, Ariana R. Dubelko, Elliot M. Frohman, Scott L. Davis; published online March 8, 2017 DOI: 10.1152/jn.00897.2016
|Fitness and the cortical response to autonomic challenge|
Listen as Katelyn Wood talks about some of the surprising findings in a study exploring the relationship between cardiorespiratory fitness and forebrain circuitry associated with cardiovascular control.
Associated article:High cardiorespiratory fitness in early to late middle-age preserves the cortical circuitry associated with brain-heart integration during volitional exercise
by Katelyn N. Wood, Torri A. Luchyshyn, J. Kevin Shoemaker; published online April 1, 2017 DOI: 10.1152/jn.00592.2016
|Voltage-gated sodium channel expression in muscle spindles|
Listen as Tim Cope and Dario Carrasco talk about their work looking at the distribution of voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles.
Associated article:Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles
by Dario I. Carrasco, Jacob A. Vincent, Timothy C. Cope; published online January 25, 2017 DOI: 10.1152/jn.00889.2016
|Can what we hear affect our sense of touch?|
Listen as Jeff Yau discusses his work investigating auditory adaptation and tactile frequency perception.
Associated article:Auditory adaptation improves tactile frequency perception
by Lexi E. Crommett, Alexis Pérez-Bellido, Jeffrey M. Yau; published online January 11, 2017 DOI: 10.1152/jn.00783.2016
|Thermoregulation and Thermal Sensitivity in Humans|
Listen as Davide Filingeri talks about his research into understanding how the human body interacts with our surrounding thermal environments, both physiologically (e.g. body temperature regulation) and perceptually (e.g. perception of temperature, wetness, touch and pain), and on how neurological diseases (e.g. Multiple Sclerosis) alter these physiological functions.
Associated article:Characteristics of the local cutaneous sensory thermo-neutral zone
by Davide Filingeri, Hui Zhang, Edward A. Arens; published online February 1, 2017 DOI: 10.1152/jn.00845.2016
|Caveolin-1 Regulates Gene Associated with Schizophrenia|
Listen as author Brian Head talks about the role of caveolin-1, a cholesterol binding and scaffolding protein that regulates neuronal signal transduction and promotes neuroplasticity, in mediating disrupted-in-schizophrenia-1 expression in neurons in vitro and the hippocampus in vivo.
Associated article:Caveolin-1 regulation of Disrupted-in-Schizophrenia-1 as a potential therapeutic target for Schizophrenia
by Adam Kassan, Junji Egawa, Zheng Zhang, Angels Almenar-Queralt, Quynh My Nguyen, Yasaman Lajevardi, Kaitlyn Kim, Edmund Posadas, Dilip V. Jeste, David M. Roth, Piyush M. Patel, Hemal H. Patel, Brian P. Head; published online November 2, 2016 DOI: 10.1152/jn.00481.2016
|Aging Effects of Neural Processing of Speech in Noise|
Listen as authors Alessandro Presacco, Jonathan Simon, and Samira Anderson talk about their investigation into how aging affects midbrain and cortical encoding of speech when presented in quiet and in noise.
Associated article:Evidence of degraded representation of speech in noise, in the aging midbrain and cortex
by Alessandro Presacco, Jonathan Z. Simon, Samira Anderson; published online August 17, 2016 DOI: 10.1152/jn.00372.2016
|The Neural Mechanisms of Decision Making|
Listen as Associate Editors Michele A. Basso (University of California, Los Angeles) and Dan M. Merfeld (Massachusetts Eye & Ear Infirmary, Harvard Medical School) summarize their contributions to our collection of articles on the neural mechanisms related to decision making and discuss the breadth and significance of the topics covered in the collection.
Associated Collection:Decision Making: Neural Mechanisms
|Development of Inhibitory Transmission in Central Circuits|
Listen as authors Caitlin Alannah McMenamin and Kirsteen Browning, both from Penn State College of Medicine, talk about their efforts to determine the critical timepoints and contributions of GABAergic versus glycinergic transmission to neurons of the dorsal motor nucleus of the vagus in the rat.
Associated article:Developmental regulation of inhibitory synaptic currents in the dorsal motor nucleus of the vagus in the rat
by Caitlin Alannah McMenamin, Laura Anselmi, R. Alberto Travagli, Kirsteen N. Browning; published online July 20, 2016 DOI: 10.1152/jn.00249.2016
|What's New at the Journal of Neurophysiology|
Read the July 2016 newsletter
|Integration of Transplanted Interneurons|
Listen as author MacKenzie Howard discusses the background and intriguing aspects of this study on how transplanted interneurons integrate into the neural circuitry of the recipient brain as well as the translational goals of this work.
Associated article:Synaptic integration of transplanted interneuron progenitor cells into native cortical networks
by MacKenzie Allen Howard, Scott C Baraban; published online May 25, 2016 DOI: 10.1152/jn.00321.2016
|Another Look at the Neurophysiology of Tactile Perception|
"This special issue is a testament to the vibrancy of the field that Steve played a major role in shaping."
Listen as Sliman Bensmaia (University of Chicago) recollects working with Steve Hsiao, summarizes his contribution to our collection of articles on the neurophysiology of tactile perception, and discusses the breadth of the somatosensory research represented in the collection.
Associated Collection:The Neurophysiology of Tactile Perception: A Tribute to Steven Hsiao
|Divergence of Retinal Information to the Brain|
Listen as authors Erika Ellis and Gabe Murphy discuss strategies to retrogradely label cells in an unbiased, robust, and specific way and several functional differences in the populations of retinal ganglion cells labeled from the two major retinorecipient brains areas.
Associated article:Shared and distinct retinal input to the mouse superior colliculus and dorsal lateral geniculate nucleus
by Erika M. Ellis, Gregory Gauvain, Benjamin Sivyer, Gabe J Murphy; published online May 11, 2016 DOI: 10.1152/jn.00227.2016
|Effects of Aging on Amplitude-Modulated Encoding in Primary Auditory Cortex|
Listen as lead author Jacqueline Overton talks about age-related changes in the spiking activity of neurons in primary auditory cortex of aged macaque monkeys.
Associated article:Effects of aging on the response of single neurons to amplitude-modulated noise in primary auditory cortex of rhesus macaque
by Jacqueline A. Overton, Gregg H. Recanzone; published June 3, 2016 DOI: 10.1152/jn.01098.2015
|Neurophysiology of Tactile Perception|
Listen as Jeff Yau (Baylor College of Medicine) describes his experience working with Steve Hsiao at Johns Hopkins University, summarizes his contribution to our collection of articles on the neurophysiology of tactile perception, and discusses the value of this collection for those involved in somatosensory research.
Associated Collection:The Neurophysiology of Tactile Perception: A Tribute to Steven Hsiao
|Visual Ecology and Potassium Conductances of Insect Photoreceptors|
Listen as Roman Frolov from the University of Oulu discusses the visual ecology and potassium conductances of photoreceptors in different species of insects characterized by highly variable lifestyles.
Associated article:Visual ecology and potassium conductances of insect photoreceptors
by Roman Frolov, Esa-Ville Immonen, Matti Weckström; published April 1, 2016 DOI: 10.1152/jn.00795.2015
|Local and Global Contributions to Hemodynamic Activity in Mouse Cortex|
Listen as the authors discuss their use of optical imaging in visual cortex of awake mice to characterize the vascular fluctuations that accompany hemodynamic activity in the brain.
Associated article:Local and global contributions to hemodynamic activity in mouse cortex
by M. Andrea Pisauro, Andrea Benucci, Matteo Carandini; published online March 16, 2016 DOI: 10.1152/jn.00125.2016
|DREADD Activation of Subfornical Organ Neurons|
Listen as the authors discuss their investigation into whether selective activation of subfornical organ neurons using virally-mediated expression of Designer Receptors Exclusively Activated by Designer Drugs, or DREADDs, stimulates thirst and salt appetite.
Associated article:DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite
by Haley L. Nation, Marvin Nicoleau, Brian J. Kinsman, Kirsteen N. Browning, Sean D. Stocker; published online March 30, 2016 DOI: 10.1152/jn.00149.2016
|Neurobiology of Deep Brain Stimulation
Listen to Editor-in-Chief Bill Yates and neurosurgeon Dr. Mark Richardson (University of Pittsburgh) discuss deep brain stimulation for some valuable insight into this treatment methodology and our collection of articles on the neurobiology of deep brain stimulation. (Image source: DOI 10.1152/jn.00275.2015)
Associated Collection:Neurobiology of Deep Brain Stimulation
|Manifestation of Acoustic Trauma in the Auditory Cortex
Listen as the authors discuss their study using single-unit electrophysiological recordings and two-photon calcium imaging in anaesthetized mice to evaluate the effects of acute acoustic trauma on the response properties of neurons in the core auditory cortex.
Associated article:Immediate manifestation of acoustic trauma in the auditory cortex is layer specific and cell type dependent
by Ondřej Novák, Ondřej Zelenka, Tomáš Hromádka, Josef Syka; published April 8, 2016 DOI: 10.1152/jn.00810.2015
|Serotonergic Fluctuations in the Male Auditory Midbrain during Courtship
Listen as the authors discuss their recent investigation into whether serotonergic fluctuations in sensory regions of the brain reflect variation within a context like opposite-sex interaction.
Associated article:Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship
by Sarah M. Keesom, Laura M. Hurley; published April 5, 2016 DOI: 10.1152/jn.00742.2015
|Ipsilateral Motor Evoked Potentials and Intracortical Inhibition
Listen as the authors discuss their recent look at whether ipsilateral motor evoked potentials (iMEPs) in the biceps brachii would be suppressed by sub-threshold conditioning, thereby demonstrating short-interval intracortical inhibition of iMEPs.
Associated article:Are ipsilateral motor evoked potentials subject to intracortical inhibition?
by Alana B. McCambridge, James W. Stinear, Winston D. Byblow; published January 20, 2016 DOI: 10.1152/jn.01139.2015.
|Oculomotor Selection Underlies Feature Retention
Listen as the authors discuss their recent work on dissociating in humans the contribution of task relevance, oculomotor selection and oculomotor execution to the retention of feature representations in working memory.
Associated article:Oculomotor selection underlies feature retention in visual working memory
by Nina Maria Hanning, Donatas Jonikaitis, Heiner Deubel, Martin Szinte; published November 18, 2015 DOI: 10.1152/jn.00927.2015.